Update on COVID-19 and oral antisepsis

Yet oth­er researchers have come to con­clu­sions sim­i­lar to the one we pub­lished on March 161 in a paper pub­lished on June 23, 2020.2 The “Results” of their “dis­cus­sion paper” read:

Oral viral load of SARS-CoV-2 has been asso­ci­at­ed with the sever­i­ty of COVID-19, and thus, a reduc­tion in the oral viral load could be asso­ci­at­ed with a decrease in the sever­i­ty of the con­di­tion. Similarly, a decrease in the oral viral load would dimin­ish the amount of virus expelled and reduce the risk of trans­mis­sion, since (i) dur­ing the first 10 days, the virus main­ly accu­mu­lates at the nasal, oral, and pha­ryn­geal area; (ii) the num­ber of angiotensin-con­vert­ing enzyme (ACE2) recep­tor is greater in the sali­vary glands as com­pared with the lungs; and (iii) sali­vary droplets rep­re­sent the most rel­e­vant trans­mis­sion route. To reduce the oral viral load, anti­sep­tic agents may be used, although the evi­dence on its effi­ca­cy is indi­rect and weak.

A group of researchers from Italy has seem­ing­ly test­ed part of the hypoth­e­sis, with a stat­ed focus on viral trans­mis­sion pre­ven­tion, in a “pilot study” of at least 39 asymp­to­matic virus car­ri­ers in vivo.3 Their results, obtained with yet oth­er viru­ci­dals than those men­tioned by us, as well as their delib­er­a­tions based on their own results and the avail­able lit­er­a­ture, may appear to sup­port loico’s ini­tial idea. We see sev­er­al rea­sons for cau­tion with regard to the study design, how­ev­er, where exact pro­ce­dures observed would need sig­nif­i­cant fur­ther clar­i­fi­ca­tion. Specifically, the authors do not dis­cuss why they believed that estab­lish­ing a con­trol group was not nec­es­sary, and what prob­a­bil­i­ty they assigned, and why, to the asymp­to­matic car­ri­ers being test­ed neg­a­tive any­way after the three days dur­ing which they were required to apply oral antisepsis.

Similar to the authors cit­ed above, the poten­tial for a role in indi­vid­ual health preser­va­tion is express­ly con­sid­ered in the “Results”:

Prevention of inner spread. It is also pos­si­ble to con­sid­er that from the sali­va (with its high viral con­tent) while the mouth is act­ing as a viral grow­ing cham­ber, the viral par­ti­cles may be aerosolized into the lungs. The con­tain­ment of viral growth in the mouth may also halt the spread­ing of the virus from the mouth to the tra­chea and into the bronchial tree.

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  1. See https://loico.com/the-logic-of-surviving-the-coronavirus-pandemic/; https://loico.com/additional-thoughts-regarding-benefit-throat-disinfection-covid-19-like-epidemics/; https://loico.com/international-researchers-pick-up-loicos-idea-of-throat-disinfection-to-counter-covid-19/; https://loico.com/update-on-preventive-throat-disinfection-antisepsis-to-counter-covid-19/; https://loico.com/some-additional-comments-on-the-design-of-the-study-conducted-by-the-university-of-kentucky/[]
  2. https://link.springer.com/article/10.1007/s00784-020-03413-2[]
  3. https://medclinres.org/pdfs/2020/virucidals-control-the-presence-of-covid-in-mouth-saliva-mcr-20.pdf[]
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Logic is all about relating individual pieces of information in a consistent way. “Consistent” means non-contradictory. An apparent tendency of two pieces of information to appear inconsistent calls for express differentiating clarification, with the logically required depth of differentiating discussion depending on the extent to which both pieces of information appear similar.
We had expressed ourselves confident to be able to predict the outcome of the 2020 US presidential election with a high degree of confidence based on financial market behavior. What we figured out – with the highest degree of confidence – was that we were maximally uncertain about the outcome (keeping us in silent consternation). Which in hindsight would appear exactly as the correct assessment to have been made.

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Logic is all about relating individual pieces of information in a consistent way. “Consistent” means non-contradictory. An apparent tendency of two pieces of information to appear inconsistent calls for express differentiating clarification, with the logically required depth of differentiating discussion depending on the extent to which both pieces of information appear similar.
We had expressed ourselves confident to be able to predict the outcome of the 2020 US presidential election with a high degree of confidence based on financial market behavior. What we figured out – with the highest degree of confidence – was that we were maximally uncertain about the outcome (keeping us in silent consternation). Which in hindsight would appear exactly as the correct assessment to have been made.
An Egyptian man takes a hostage at knifepoint in the Milan cathedral, threatening to slit his victim’s throat. A once reputable Italian paper tells its readers that police “convinced him to lay down his weapon and release the hostage”, when in fact, for everyone to see on video, police had to forcefully overwhelm him. The full and unredacted video, in turn, explodes on social media.