Update on preventive throat disinfection / antisepsis to counter COVID-19

Additional infor­ma­tion has come to our atten­tion with regard to our ini­tial pro­pos­al for pre­ven­tive throat disinfection/antisepsis to counter COVID-19.

Five days after we called for clin­i­cal stud­ies to be con­duct­ed to test our pro­pos­al in our “Additional thoughts”1, researchers from the University of Kentucky have post­ed a tri­al employ­ing one of the sub­stances we had men­tioned as effec­tive against coro­n­avirus­es to the clinicaltrials.gov web­site.2

Specifically:

“In this study, front line health­care work­ers will be asked to com­plete a pre-par­tic­i­pa­tion sur­vey and screened for COVID pos­i­tiv­i­ty. They will then be giv­en pre­made PVP-I gar­gles and nasal sprays, as well as a cal­en­dar card to mark com­pli­ance. PVP-I nasal spray and gar­gle (10% dilut­ed 1:30) will be used pri­or to the start of a shift, dur­ing “lunch break”, and at the end of shift. First, the nasal spray will be sprayed in the nose (2 sprays each naris). For ade­quate cov­er­age, the par­tic­i­pant should be able to taste the iodine or see it in the back of the throat. This should be left in place for 30 sec­onds. Then, the par­tic­i­pant will gar­gle the solu­tion for 30 sec­onds and not have any­thing to eat or drink by mouth for 30 min­utes. Treatment will con­tin­ue for 3 weeks, or until the health­care work­er presents with COVID symp­toms. Participants will then be test­ed for COVID pos­i­tiv­i­ty and asked to fill out a sec­ond ques­tion­naire assess­ing study tolerability.”

The tri­al has report­ed­ly start­ed one day lat­er, and is expect­ed to be com­plet­ed by May 2021. The tri­al design appears to dis­re­gard, unfor­tu­nate­ly, the time of day we have pos­tu­lat­ed – in accor­dance with a pri­or arti­cle by US pul­mo­nolo­gist Bruce L. Davidson MD3 -, as being like­ly the most impor­tant one for pneu­mo­nia pre­ven­tion, name­ly before going to sleep.4

In addi­tion, study results were pub­lished yes­ter­day with regard to effi­ca­cy of the same sub­stance against COVID-19 in vit­ro.5

Title: “In Vitro Efficacy of Povidone-Iodine Nasal And Oral Antiseptic Preparations Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)

Results: “All con­cen­tra­tions of nasal anti­sep­tics and oral rinse anti­sep­tics eval­u­at­ed com­plete­ly inac­ti­vat­ed the SARS-CoV-2 virus. Conclusions: Nasal and oral PVP-I anti­sep­tic solu­tions are effec­tive at inac­ti­vat­ing the SARS-CoV-2 virus at a vari­ety of con­cen­tra­tions after 60s expo­sure times.

This, too, appears to indi­cate that a wider inter­est in the idea we have put for­ward on March 16 has recent­ly begun to emerge.

_____
  1. https://loico.com/additional-thoughts-regarding-benefit-throat-disinfection-covid-19-like-epidemics/[]
  2. https://clinicaltrials.gov/ct2/show/NCT04364802[]
  3. https://edition.cnn.com/2020/03/12/opinions/coronavirus-vulnerability-while-sleeping-bruce-davidson/index.html[]
  4. https://loico.com/the-logic-of-surviving-the-coronavirus-pandemic/[]
  5. https://www.medrxiv.org/content/10.1101/2020.05.25.20110239v1[]
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What is the essence of someone pretending not to notice the essential aspect of the central allegation with respect to an essential matter to which he is an interested party, implicitly saying A while stating B? A refusal to engage in rational dialogue, which in turn is the only way to ultimately avert violence: an implicit declaration of (civil) war.

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What is the essence of someone pretending not to notice the essential aspect of the central allegation with respect to an essential matter to which he is an interested party, implicitly saying A while stating B? A refusal to engage in rational dialogue, which in turn is the only way to ultimately avert violence: an implicit declaration of (civil) war.