Update on preventive throat disinfection / antisepsis to counter COVID-19

Additional infor­ma­tion has come to our atten­tion with regard to our ini­tial pro­pos­al for pre­ven­tive throat disinfection/antisepsis to counter COVID-19.

Five days after we called for clin­i­cal stud­ies to be con­duct­ed to test our pro­pos­al in our “Additional thoughts”1, researchers from the University of Kentucky have post­ed a tri­al employ­ing one of the sub­stances we had men­tioned as effec­tive against coro­n­avirus­es to the clinicaltrials.gov web­site.2

Specifically:

“In this study, front line health­care work­ers will be asked to com­plete a pre-par­tic­i­pa­tion sur­vey and screened for COVID pos­i­tiv­i­ty. They will then be giv­en pre­made PVP-I gar­gles and nasal sprays, as well as a cal­en­dar card to mark com­pli­ance. PVP-I nasal spray and gar­gle (10% dilut­ed 1:30) will be used pri­or to the start of a shift, dur­ing “lunch break”, and at the end of shift. First, the nasal spray will be sprayed in the nose (2 sprays each naris). For ade­quate cov­er­age, the par­tic­i­pant should be able to taste the iodine or see it in the back of the throat. This should be left in place for 30 sec­onds. Then, the par­tic­i­pant will gar­gle the solu­tion for 30 sec­onds and not have any­thing to eat or drink by mouth for 30 min­utes. Treatment will con­tin­ue for 3 weeks, or until the health­care work­er presents with COVID symp­toms. Participants will then be test­ed for COVID pos­i­tiv­i­ty and asked to fill out a sec­ond ques­tion­naire assess­ing study tolerability.”

The tri­al has report­ed­ly start­ed one day lat­er, and is expect­ed to be com­plet­ed by May 2021. The tri­al design appears to dis­re­gard, unfor­tu­nate­ly, the time of day we have pos­tu­lat­ed – in accor­dance with a pri­or arti­cle by US pul­mo­nolo­gist Bruce L. Davidson MD3 -, as being like­ly the most impor­tant one for pneu­mo­nia pre­ven­tion, name­ly before going to sleep.4

In addi­tion, study results were pub­lished yes­ter­day with regard to effi­ca­cy of the same sub­stance against COVID-19 in vit­ro.5

Title: “In Vitro Efficacy of Povidone-Iodine Nasal And Oral Antiseptic Preparations Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)

Results: “All con­cen­tra­tions of nasal anti­sep­tics and oral rinse anti­sep­tics eval­u­at­ed com­plete­ly inac­ti­vat­ed the SARS-CoV-2 virus. Conclusions: Nasal and oral PVP-I anti­sep­tic solu­tions are effec­tive at inac­ti­vat­ing the SARS-CoV-2 virus at a vari­ety of con­cen­tra­tions after 60s expo­sure times.

This, too, appears to indi­cate that a wider inter­est in the idea we have put for­ward on March 16 has recent­ly begun to emerge.

_____
  1. https://loico.com/additional-thoughts-regarding-benefit-throat-disinfection-covid-19-like-epidemics/[]
  2. https://clinicaltrials.gov/ct2/show/NCT04364802[]
  3. https://edition.cnn.com/2020/03/12/opinions/coronavirus-vulnerability-while-sleeping-bruce-davidson/index.html[]
  4. https://loico.com/the-logic-of-surviving-the-coronavirus-pandemic/[]
  5. https://www.medrxiv.org/content/10.1101/2020.05.25.20110239v1[]
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Logic is all about relating individual pieces of information in a consistent way. “Consistent” means non-contradictory. An apparent tendency of two pieces of information to appear inconsistent calls for express differentiating clarification, with the logically required depth of differentiating discussion depending on the extent to which both pieces of information appear similar.
We had expressed ourselves confident to be able to predict the outcome of the 2020 US presidential election with a high degree of confidence based on financial market behavior. What we figured out – with the highest degree of confidence – was that we were maximally uncertain about the outcome (keeping us in silent consternation). Which in hindsight would appear exactly as the correct assessment to have been made.

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Logic is all about relating individual pieces of information in a consistent way. “Consistent” means non-contradictory. An apparent tendency of two pieces of information to appear inconsistent calls for express differentiating clarification, with the logically required depth of differentiating discussion depending on the extent to which both pieces of information appear similar.
We had expressed ourselves confident to be able to predict the outcome of the 2020 US presidential election with a high degree of confidence based on financial market behavior. What we figured out – with the highest degree of confidence – was that we were maximally uncertain about the outcome (keeping us in silent consternation). Which in hindsight would appear exactly as the correct assessment to have been made.
An Egyptian man takes a hostage at knifepoint in the Milan cathedral, threatening to slit his victim’s throat. A once reputable Italian paper tells its readers that police “convinced him to lay down his weapon and release the hostage”, when in fact, for everyone to see on video, police had to forcefully overwhelm him. The full and unredacted video, in turn, explodes on social media.